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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

ChREBP Blocking Peptide

Cayman Chemical Item Number 10006790

WBSCR14; Carbohydrate Response Element-binding Protein

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Description

ChREBP (carbohydrate response element-binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NSL) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine-zipper-like (Zip-like) domain.1 ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney, white and brown adipose tissue.2 Under basal conditions ChREBP is localized in the cytosol and upon high glucose stimulation the protein is translocated into the nucleus following its dephosphorylation of phospho-Ser196.1 Murine ChREBP is 864 amino acids in length with an estimated molecular weight of about 95 kDa. Cayman’s ChREBP polyclonal antibody detects a specific band at 100 kDa in tissues and cells such as liver, white fat, and Hep-G2 cells.

1 Uyeda, K., Yamashita, H., and Kawaguchi, T. Carbohydrate responsive element-binding protein (ChREBP): A key regulator of glucose metabolism and fat storage. Biochem Pharmacol 63 2075-2080 (2002).

2 Iizuka, K., Bruick, R.K., Liang, G., et al. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 101(19) 7281-7286 (2004).

Synonyms
  • WBSCR14
  • Carbohydrate Response Element-binding Protein
Formulation 200 µg lyophilized peptide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Uyeda, K., Yamashita, H., and Kawaguchi, T. Carbohydrate responsive element-binding protein (ChREBP): A key regulator of glucose metabolism and fat storage. Biochem Pharmacol 63 2075-2080 (2002).

Iizuka, K., Bruick, R.K., Liang, G., et al. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 101(19) 7281-7286 (2004).

Kawaguchi, T., Takenoshita, M., Kabashima, T., et al. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci USA 98(24) 13710-13715 (2001).

Ishii, S., Iizuka, K., Miller, B.C., et al. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci USA 101(44) 15597-15602 (2004).

Yamashita, H., Takenoshita, M., Sakurai, M., et al. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc Natl Acad Sci USA 98(16) 9116-9121 (2001).

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This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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ChREBP Transcription Factor Assay Kit
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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