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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

O-1602

Cayman Chemical Item Number 10006803

(CAS 317321-41-8)

O-1602 (CAS 317321-41-8)

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Description

Abnormal cannabidiol is a synthetic regioisomer of cannabidiol that fails to elicit either CB1 or CB2 responsiveness and is without psychotropic activity. It induces endothelium-dependent vasodilation via a CB1/CB2/nitric oxide-independent mechanism.1 O-1602 is a cannabidiol analog with close structural similarity to O-1918 which is a selective antagonist of abnormal cannabidiol at the non-CB1/CB2 endothelial receptor.2 O-1918 does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of abnormal cannabidiol in vitro and in whole animals.2 The biological activity of O-1821 has not been reported.

1 Járai, Z., Wagner, J.A., Varga, K., et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA 96(24) 14136-14141 (1999).

2 Offertáler, L., Mo, F., Bátkai, S., et al. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol 63(3) 699-705 (2003).

Formal Name 5-​methyl-​4-​[(1R,​6R)-​3-​methyl-​6-​(1-​methylethenyl)-​2-​cyclohexen-​1-​yl]-​1,​3-​benzenediol
CAS Number 317321-41-8
Molecular Formula C17H22O2
Formula Weight 258.4
Formulation A solution in methyl acetate
Purity >98%
λmax 206, 281 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC1=C[C@@H]​(C2=C(O)​C=C(O)​C=C2C)​[C@H]​(C(C)​=C)​CC1

Background Reading

Járai, Z., Wagner, J.A., Varga, K., et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA 96(24) 14136-14141 (1999).

Sabirsh, A., Pettersson, A., Boketoft, K., et al. Differential inhibition of receptor activation by two mouse monoclonal antibodies specific for the human leukotriene B4 receptor, BLT1. Int Immunopharmacol 3 1829-1839 (2003).

O-1602 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $22.00 $0.00
5 mg $88.00 $0.00
10 mg $132.00 $0.00
25 mg $248.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Cannabidiol
CAY10429
O-1821
O-1918
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