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N-HBG

Cayman Chemical Item Number 10006859

(CAS 140215-98-1)

N-HBG (CAS 140215-98-1)

See more	Enzyme Activity (146) Nitric Oxide (101)

Description

Three distinct isoforms of nitric oxide synthase (NOS), nNOS/NOS I, iNOS/NOS II, and eNOS/NOS III, catalyze the oxidation of arginine to citrulline and NO with N^ω-hydroxy-L-arginine (NOHA) formed as an intermediate.^1,2,3 N-HBG is a NOHA analog in which both the α-NH2 and α-COOH groups have been removed. It serves as an efficient substrate for all three NOS isoforms, being oxidized to NO at rates of 65% (nNOS), 68% (iNOS) and 41% (eNOS) relative to NOHA.⁴

1 Marletta, M.A., Hurshman, A.R., and Rusche, K.M. Catalysis by nitric oxide synthase. Curr Opin Chem Biol 2 656-663 (1998).

2 Stuehr, D.J. Mammalian nitric oxide synthases. Biochim Biophys Acta 1411 217-230 (1999).

3 Alderton, W.K., Cooper, C.E., and Knowles, R.G. Nitric oxide synthases: Structure, function, and inhibition. Biochem J 357 593-615 (2001).

4 Dijols, S., Perollier, C., Lefevre-Groboillot, D., et al. Oxidation of Nw-hydroxyarginine analogues by NO-synthase: The simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as Nw-hydroxyarginine. J Med Chem 44(20) 3199-3202 (2001).

Formal Name	N-butyl-N¿-hydroxy-guanidine
CAS Number	140215-98-1
Molecular Formula	C₅H₁₃N₃O
Formula Weight	131.2
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCN\C(=N\O)\N

Background Reading

Alderton, W.K., Cooper, C.E., and Knowles, R.G. Nitric oxide synthases: Structure, function, and inhibition. Biochem J 357 593-615 (2001).

Marletta, M.A., Hurshman, A.R., and Rusche, K.M. Catalysis by nitric oxide synthase. Curr Opin Chem Biol 2 656-663 (1998).

Stuehr, D.J. Mammalian nitric oxide synthases. Biochim Biophys Acta 1411 217-230 (1999).

Dijols, S., Perollier, C., Lefevre-Groboillot, D., et al. Oxidation of Nw-hydroxyarginine analogues by NO-synthase: The simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as Nw-hydroxyarginine. J Med Chem 44(20) 3199-3202 (2001).

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N-HBG is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$27.00		$0.00
5 mg	$122.00		$0.00
10 mg	$216.00		$0.00
25 mg	$473.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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N-HFG

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