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Docosahexaenoic Acid methyl ester

Cayman Chemical Item Number 10006865

Cervonic Acid methyl ester; DHA methyl ester (CAS 2566-90-7)

Docosahexaenoic Acid methyl ester (CAS 2566-90-7)

See more	Fatty Acids (267) Hypertension (90) Neuroscience (654) Nutrition/Diet (64)

Description

Docosahexaenoic acid (DHA) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. DHA constitutes as much as 40% of the total polyunsaturated fatty acid pool in retinal and neuronal membranes.¹ Supplementation of dietary DHA using fish oil inhibits the progression of atherosclerosis and delays photoreceptor degeneration in retinitis pigmentosa.² Neonatal DHA deprivation causes developmental defects and can lead to hypertension in rats.³ DHA methyl ester is an ester version of the free acid which is less water soluble, but more amenable for the formulation of fatty acid-containing diets and dietary supplements.⁴

1 Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317 (1986).

2 Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res 60 279-289 (1995).

3 Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7(3) 258-259 (2001).

4 Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B₄ receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

Synonyms	Cervonic Acid methyl ester DHA methyl ester
Formal Name	4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid, methyl ester
CAS Number	2566-90-7
Molecular Formula	C₂₃H₃₄O₂
Formula Weight	342.5
Formulation	A solution in ethanol
Purity	≥98%
Stability	6 months
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)OC

Background Reading

Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317 (1986).

Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B₄ receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).

Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7(3) 258-259 (2001).

Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res 60 279-289 (1995).

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Docosahexaenoic Acid methyl ester is available in the following screening library:

Fatty Acid Screening Library (96-Well)

Size	Price	Quantity	Subtotal
50 mg	$19.00		$0.00
100 mg	$36.00		$0.00
500 mg	$152.00		$0.00
1 g	$266.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

4,5-dehydro Docosahexaenoic Acid

Docosahexaenoic Acid

Docosahexaenoic Acid-d₅

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