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Diethylstilbestrol

Cayman Chemical Item Number 10006876

(CAS 56-53-1)

Diethylstilbestrol (CAS 56-53-1)

See more	Receptor Biochemistry (59) Steroids (37) Cancer (606) Endocrinology (335)

Description

Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring.¹ DES is structurally related to, and is as potent as, estradiol in most assays, with a longer half-life. It has a relative binding affinity to sex hormone binding globulin (SHBG) of 0.2 compared to estradiol which has a relative binding affinity of 100. A concentration of 20 µM DES, displaces 30 ± 13% of 3H-estradiol from SHBG in serum.^1,2

1 Coelingh Bennink, H.J.T. Are all estrogens the same? Maturitas 47 269-275 (2003).

2 Jury, H.H., Zaxharewski, T.R., and Hammond, G.L. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol 75 167-176 (2000).

Formal Name	4,4'[(1E)-1,2-diethyl-1,2-ethenediyl]bis-phenol
CAS Number	56-53-1
Molecular Formula	C₁₈H₂₀O₂
Formula Weight	268.4
Formulation	A crystalline solid
Purity	≥98%
λ_max	240 nm
Stability	2 months
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC\C(=C(\CC)/c1ccc(O)cc1)\c1ccc(O)cc1

Background Reading

Coelingh Bennink, H.J.T. Are all estrogens the same? Maturitas 47 269-275 (2003).

Jury, H.H., Zaxharewski, T.R., and Hammond, G.L. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol 75 167-176 (2000).

Diethylstilbestrol is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 g	$20.00		$0.00
5 g	$90.00		$0.00
10 g	$160.00		$0.00
25 g	$350.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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