8,12-iso-iPF2α-VI-d11

8,12-iso-iPF_2α-VI-d₁₁ Exclusive

Cayman Chemical Item Number 10006878

8,12-epi-iPF_2α-VI-d₁₁

Description

8,12-iso-isoprostane F_2α-VI-d₁₁ (8,12-iso-iPF_2α-VI-d₁₁) contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8,12-iso-iPF_2α-VI by GC- or LC-mass spectrometry. The relative abundance of deuterium atoms incorporated into each molecule has not been determined. Cayman certifies that less that 1% of the product has no deuterium incorporation (<1% d0). Isoprostanes are non-enzymatic, non-cyclooxygenase prostanoid products of peroxidative damage to membrane lipids.¹ Among the many isoprostane isomers, 8,12-iso-iPF_2α-VI has been demonstrated to be one of the predominant isomers formed and is also present in urine as one of the major isoprostane products.² 8,12-iso-iPF_2α-VI-d₁₁ is a deuterated internal standard for use in isoprostane quantitation by mass spec modalities. The compound is diastereomeric at C-5, but is otherwise an optically active, single enantiomer.

1 Diaz, M.N., Frei, B., Vita, J.A., et al. Antoixidants and atherosclerotic heart disease. N Engl J Med 337 408-416 (1997).

2 Lawson, J.A., Li, H., Rokach, J., et al. Identification of two major F₂ isoprostanes, 8,12-iso- and 5-epi-8,12-iso-isoprostane F_2α-VI, in human urine. J Biol Chem 273 29295-29301 (1998).

Synonyms

8,12-epi-iPF2α-VI-d11

Formal Name

5S,5R,9α,11α-trihydroxy-(12α)-prosta-6E,14Z-dien-1-oic-16,16,17,17,18,18,19,19,20,20,20-d11 acid

Molecular Formula

C₂₀H₂₃D₁₁O₅

Formula Weight

365.6

Formulation

A solution in acetonitrile

Purity

≥99% deuterated forms (d1-d11)

Stability

1 year

Storage

-80°C

Shipping

Dry ice in continental US; may vary elsewhere

SMILES

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CCCCC/C=C\CC1C(O)CC(O)C1\C=C\C(O)CCCC(=O)O

Background Reading

Diaz, M.N., Frei, B., Vita, J.A., et al. Antoixidants and atherosclerotic heart disease. N Engl J Med 337 408-416 (1997).

Lawson, J.A., Li, H., Rokach, J., et al. Identification of two major F₂ isoprostanes, 8,12-iso- and 5-epi-8,12-iso-isoprostane F_2α-VI, in human urine. J Biol Chem 273 29295-29301 (1998).

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10 µg 
$149.00

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25 µg 
$354.00

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50 µg 
$671.00

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100 µg 
$1,192.00

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