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Renin Fluorogenic Substrate

Cayman Chemical Item Number 10006906

See more	Enzyme Activity (151) Enzyme Substrates (8) Endocrinology (337) Hypertension (97) Renal Disease (34)

Description

Renin is an aspartyl protease of approximately 40 kDa that converts angiotensinogen into angiotensin I.¹ The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other.² After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm.

1 Imai, T., Miyazaki, H., Hirose, S., et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci USA 80 7405-7409 (1983).

2 Wang, G.T., Chung, C.C., Holzman, T.F., et al. A continuous fluorescence assay of renin activity. Anal Biochem 210 351-359 (1993).

Formal Name	Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(Dabcyl)-Arg-OH
Formula Weight	2282.7
Formulation	A red/brown crystalline solid
Purity	>95%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Imai, T., Miyazaki, H., Hirose, S., et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci USA 80 7405-7409 (1983).

Wang, G.T., Chung, C.C., Holzman, T.F., et al. A continuous fluorescence assay of renin activity. Anal Biochem 210 351-359 (1993).

Size	Price	Quantity	Subtotal
1 mg	$250.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Renin Substrate

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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