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Pravadoline

Cayman Chemical Item Number 10006973

WIN 48,098 (CAS 92623-83-1)

Pravadoline (CAS 92623-83-1)

See more	Cannabinoids (333) NSAIDS (24) Forensic Science (369) Inflammation (396) Pain (151)

Description

Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.¹ Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC₅₀ = 5 μM in mouse brain microsomes) and displays antinociceptive activity (ED₅₀ = 26 mg/kg in an acetylcholine-induced writhing assay in mice).¹ In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC₅₀ = 0.45 μM), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone.¹ Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.¹

1 D'Ambra, T.E., Estep, K.G., Bell, M.R., et al. Conformationally restrained analogues of pravadoline: Nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J Med Chem 35 124-135 (1992).

Synonyms	WIN 48,098
Formal Name	(4-methoxyphenyl)[2-methyl]-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone
CAS Number	92623-83-1
Molecular Formula	C₂₃H₂₆N₂O₃
Formula Weight	378.5
Formulation	A crystalline solid
Purity	≥98%
λ_max	219, 272, 322 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC1=C(C(C2=CC=C(OC)C=C2)=O)C3=C(N1CCN4CCOCC4)C=CC=C3

Pravadoline is available in the following screening library:

Cannabinoid Agonist Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$56.00		$0.00
10 mg	$106.00		$0.00
25 mg	$252.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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