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AM630

Cayman Chemical Item Number 10006974

Iodopravadoline (CAS 164178-33-0)

AM630 (CAS 164178-33-0)

See more	Cannabinoids (333) Receptor Antagonist (94) Forensic Science (369) Neuroscience (725) Pain (151)

Description

Cannabinoids produce biochemical and pharmacological effects by interacting with the central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) G protein-coupled receptors. AM630 is a selective CB₂ receptor antagonist that binds to CB₁ and CB₂ receptors with K_i values of 5.2 µM and 31.2 nM, respectively.¹ AM630 behaves as an inverse agonist at CB₂ receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB₁ receptors. ^1,2,3

1 Ross, R.A., Brockie, H.C., Stevenson, L.A., et al. Agonist-inverse agonist characterization at CB₁ and CB₂ cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol 126 665-672 (1999).

2 Malan, T.P., Ibrahim, M.M., Deng, H., et al. CB₂ cannabinoid receptor-mediated peripheral antinociception. Pain 93 239-245 (2001).

3 Bisogno, T., Ortar, G., Petrosino, S., et al. Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. Biochem Biophys Acta 1791 53-60 (2009).

Synonyms	Iodopravadoline
Formal Name	[6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone
CAS Number	164178-33-0
Molecular Formula	C₂₃H₂₅IN₂O₃
Formula Weight	504.4
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2cc(I)ccc12

Background Reading

Malan, T.P., Ibrahim, M.M., Deng, H., et al. CB₂ cannabinoid receptor-mediated peripheral antinociception. Pain 93 239-245 (2001).

Bisogno, T., Ortar, G., Petrosino, S., et al. Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. Biochem Biophys Acta 1791 53-60 (2009).

Ross, R.A., Brockie, H.C., Stevenson, L.A., et al. Agonist-inverse agonist characterization at CB₁ and CB₂ cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol 126 665-672 (1999).

Size	Price	Quantity	Subtotal
5 mg	$35.00		$0.00
10 mg	$67.00		$0.00
50 mg	$280.00		$0.00
100 mg	$490.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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