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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

AM630

Cayman Chemical Item Number 10006974

Iodopravadoline (CAS 164178-33-0)

AM630 (CAS 164178-33-0)

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Description

Cannabinoids produce biochemical and pharmacological effects by interacting with the central cannabinoid (CB1) and peripheral cannabinoid (CB2) G protein-coupled receptors. AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 µM and 31.2 nM, respectively.1 AM630 behaves as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. 1,2,3

1 Ross, R.A., Brockie, H.C., Stevenson, L.A., et al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol 126 665-672 (1999).

2 Malan, T.P., Ibrahim, M.M., Deng, H., et al. CB2 cannabinoid receptor-mediated peripheral antinociception. Pain 93 239-245 (2001).

3 Bisogno, T., Ortar, G., Petrosino, S., et al. Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. Biochem Biophys Acta 1791 53-60 (2009).

Synonyms
  • Iodopravadoline
Formal Name [6-​iodo-​2-​methyl-​1-​[2-​(4-​morpholinyl)ethyl]-​1H-​indol-​3-​yl](4-​methoxyphenyl)-​methanone
CAS Number 164178-33-0
Molecular Formula C23H25IN2O3
Formula Weight 504.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(cc1)​C(=O)​c1c(C)​n(CCN2CCOCC2)​c2cc(I)​ccc12

Background Reading

Malan, T.P., Ibrahim, M.M., Deng, H., et al. CB2 cannabinoid receptor-mediated peripheral antinociception. Pain 93 239-245 (2001).

Bisogno, T., Ortar, G., Petrosino, S., et al. Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. Biochem Biophys Acta 1791 53-60 (2009).

Ross, R.A., Brockie, H.C., Stevenson, L.A., et al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol 126 665-672 (1999).
Size Price Quantity Subtotal
5 mg $35.00 $0.00
10 mg $67.00 $0.00
50 mg $280.00 $0.00
100 mg $490.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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