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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Thiocarlide

Cayman Chemical Item Number 10006976

Isoxyl (CAS 910-86-1)

Thiocarlide (CAS 910-86-1)

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Description

Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml.1,2 At concentrations of 10 µM, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drugs. Unlike INH and ETH, isoxyl also partially inhibits the synthesis of fatty acids. Isoxyl shows no acute toxicity against primary macrophage cell cultures as demonstrated by diminution of redox activity.2

1 Phetsuksiri, B., Jackson, M., Scherman, H., et al. Unique mechanism of action of the thiourea drug isoxyl on mycobacterium tuberculosis. J Biol Chem 278(52) 53123-53130 (2003).

2 Phetsuksiri, B., Baulard, A.R., Cooper, A.M., et al. Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis. Antimicrob Agents Chemother 43(5) 1042-1051 (1999).

Synonyms
  • Isoxyl
Formal Name N,​N'-​bis[4-​(3-​methylbutoxy)phenyl]-​thiourea
CAS Number 910-86-1
Molecular Formula C23H32N2O2S
Formula Weight 400.6
Formulation A crystalline solid
Purity >98%
λmax 273 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​CCOc1ccc(cc1)​NC(=S)​Nc1ccc(OCCC(C)​C)​cc1

Background Reading

Phetsuksiri, B., Jackson, M., Scherman, H., et al. Unique mechanism of action of the thiourea drug isoxyl on mycobacterium tuberculosis. J Biol Chem 278(52) 53123-53130 (2003).

Phetsuksiri, B., Baulard, A.R., Cooper, A.M., et al. Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis. Antimicrob Agents Chemother 43(5) 1042-1051 (1999).

Thiocarlide is available in the following screening library:

Size Price Quantity Subtotal
50 mg $22.00 $0.00
100 mg $42.00 $0.00
500 mg $176.00 $0.00
1 g $308.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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