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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

LPA1 Blocking Peptide

Cayman Chemical Item Number 10006984

Vzg-1; LPAR1; LPA Receptor 1; EDG-2

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Description

Peptide sequence: human Lysophosphatidic Acid Receptor 1 (LPA1) amino acids 342-359 · To be used in conjunction with Cayman’s LPA1 polyclonal antibody (Catalog No. 10005280) to block protein-antibody complex formation during immunochemical analysis of LPA1. · LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4).1 LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5).2 LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element, and cell proliferation.3,4 LPA1 mRNA is detected in a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.5,6 Murine and human LPA1 have 364 amino acids with an estimated molecular weight of 41 kDa.4 Cayman’s LPA1 polyclonal antibody detects the protein from several species at 43-50 kDa, suggesting heterogeneous LPA1 post-translational modifications in distinct cells.

1 Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278(28) 25600-25606 (2003).

2 Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002).

3 Fukushima, N., and Chun, J. The LPA receptors. Prostaglandins Other Lipid Mediat 64 21-32 (2001).

4 Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annu Rev Biochem 73 321-354 (2004).

5 Contos, J.J.A., and Chun, J. The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene 267 243-253 (2001).

6 An, S., Bleu, T., Hallmark, O.G., et al. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 273(14) 7906-7910 (1998).

Synonyms
  • Vzg-1
  • LPAR1
  • LPA Receptor 1
  • EDG-2
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4 containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Noguchi, K., Ishii, S., and Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278(28) 25600-25606 (2003).

Contos, J.J.A., and Chun, J. The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene 267 243-253 (2001).

An, S., Bleu, T., Hallmark, O.G., et al. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 273(14) 7906-7910 (1998).

Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology. Annu Rev Biochem 73 321-354 (2004).

Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002).

Fukushima, N., and Chun, J. The LPA receptors. Prostaglandins Other Lipid Mediat 64 21-32 (2001).

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1 ea $107.00 $0.00
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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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LPA1 Polyclonal Antibody

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