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Piloty’s AcidCayman Chemical Item Number 10006995 Benzenesulphonydroxamic acid (CAS 599-71-3) 
Piloty's Acid (CAS 599-71-3)
Description
Nitric Oxide (NO) is a free radical gas that is involved in a variety of biological processes including regulation vascular tone, neuronal signaling, and host defense.1,2 Nitroxyl (HNO) is the one electron reduced form of nitric oxide. Piloty’s acid is one of the best known and most widely used HNO donors. Under basic conditions Piloty’s acid decomposes to HNO and benzenesulfinate anion. The rate of HNO release at pH 7 is very slow (t1/2 = 5500 minutes) making its use most effective above pH 8.0. The half-
1 Beckman, J.S., and Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am J Physiol 271 C1424-C1437 (1996). 2 Bredt, D.S., and Snyder, S.H. Nitric oxide: A physiologic messenger molecule. Annu Rev Biochem 63 175-195 (1994). 3 hughes, M.N., and Cammack, R. Synthesis, chemistry, and application of nitroxyl ion releasers sodium trioxodinitrate or Angeli’s Salt and Piloty’s Acid. Methods Enzymol 301 279-287 (1999).
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Nagasawa, H.T., Kawle, S.P., Elberling, J.A., et al. Prodrugs of nitroxyl as potential aldehyde dehydrogenase inhibitors vis-
Background ReadingBredt, D.S., and Snyder, S.H. Nitric oxide: A physiologic messenger molecule. Annu Rev Biochem 63 175-195 (1994). hughes, M.N., and Cammack, R. Synthesis, chemistry, and application of nitroxyl ion releasers sodium trioxodinitrate or Angeli’s Salt and Piloty’s Acid. Methods Enzymol 301 279-287 (1999). Beckman, J.S., and Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am J Physiol 271 C1424-C1437 (1996). Nagasawa, H.T., Kawle, S.P., Elberling, J.A., et al. Prodrugs of nitroxyl as potential aldehyde dehydrogenase inhibitors vis- Piloty's Acid is available in the following screening library: |
This product is available in custom sizes and/or larger quantities. Please contact our Sales Department for a quote or to purchase. Pricing updated 2012-05-25. Prices are subject to change without notice. To ask for assistance with one of our products please contact a Technical Support Scientist. Warning This product is not for human or veterinary use. Related Products
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