Cayman Chemical | (±)-14,15-DiHETE-dx | Description • (±)14,15-Dihydroxy-Eicosa-5,8,11,17-Tetraenoic Acid; 116477-54-4

10006998 (±)-14,15-DiHETE-dx

(±)14,15-Dihydroxy-Eicosa-5,8,11,17-Tetraenoic Acid; 116477-54-4

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• See more Fatty Acids; Oxylipins; Cytochrome P450; Nutrition/Diet; Oxidative Injury

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Eicosapentaenoic acid (EPA) is an ω-3 fatty acid abundantly available in marine organisms. 14,15-DiHETE is one of the major metabolites produced when EPA is incubated with rat liver microsomes and a rat colitis homogenate.^1,2 The route of production likely proceeds through cytochrome P450-catalyzed epoxidation at the ω-6 double bond followed by conversion to the vicinal diols by epoxide hydrolase.³ 14,15-DiHETE is excreted in significant quantities by humans ingesting fish oil supplements.⁴

1 VanRollins, M., Frade, P.D., Carretero, O.A. Oxidation of 5,8,11,14,17-eicosapentaenoic acid by hepatic and renal microsomes. Biochim Biophys Acta 996 133-149 (1988).

2 Yamane, M., Abe, A., Yamane, S. High-performance liquid chromatography-thermospray mass spectrometry of epoxy polyunsaturated fatty acids and epoxyhydroxy polyunsaturated fatty acids from an incubation mixture of rat tissue homogenate. Journal of Chromatography B 652 123-136 (1994).

3 VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes. J Biol Chem 259 5776-5783 (1984).

4 Knapp, H.R., Miller, A.J., Lawson, J.A. Urinary excretion of diols derived from eicosapentaenoic acid during N-3 fatty acid ingestion. Prostaglandins 42 47-53 (1991).

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Pricing updated 2010-03-16.
Prices are subject to change without notice.

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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.