Cayman Chemical | PTEN Blocking Peptide | Description • Phosphatase and Tensin Homology on Chromosome 10

10007073 PTEN Blocking Peptide

Phosphatase and Tensin Homology on Chromosome 10

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• See more Immunohistochemistry; Western Blot; Cancer

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Peptide sequence: human PTEN amino acids 254-270 · To be used in conjunction with Cayman’s PTEN polyclonal antibody (Catalog No. 10005059) to block protein-antibody complex formation during immunochemical analysis of PTEN · PTEN dephosphorylates proteins and lipids such as AKT and phosphatidylinositol 3,4,5-triphosphate (PIP₃) and therefore functions as a key regulatory enzyme in a central signal transduction pathway. PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.¹ PTEN interacts with many other proteins to regulate cell division and migration as well as promoting apoptosis when necessary.² Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma.^3,4

1 Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nature Genet 15 356-362 (1997).

2 Di Cristofano, A., Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100 387-390 (2000).

3 Vivanco, I., Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nature Reviews Cancer 2 489-501 (2002).

4 Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocrine-Related Cancer 7 115-129 (2000).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.

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