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PTEN Blocking Peptide

Cayman Chemical Item Number 10007073

Phosphatase and Tensin Homology on Chromosome 10

See more	Immunohistochemistry (208) Western Blot (557) Cancer (606)

Description

Peptide sequence: human PTEN amino acids 254-270 · To be used in conjunction with Cayman’s PTEN polyclonal antibody (Catalog No. 10005059) to block protein-antibody complex formation during immunochemical analysis of PTEN · PTEN dephosphorylates proteins and lipids such as AKT and phosphatidylinositol 3,4,5-triphosphate (PIP₃) and therefore functions as a key regulatory enzyme in a central signal transduction pathway. PTEN is expressed in almost all tissues of the body as a 403 amino acid protein with an estimated molecular weight of 47 kDa, however the actual migration observed on western blot may vary among distinct samples.¹ PTEN interacts with many other proteins to regulate cell division and migration as well as promoting apoptosis when necessary.² Mutation of PTEN results in many human cancers including melanoma and prostate carcinoma.^3,4

1 Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15 356-362 (1997).

2 Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100 387-390 (2000).

3 Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

4 Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7 115-129 (2000).

Synonyms	Phosphatase and Tensin Homology on Chromosome 10
Formulation	200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Steck, P.A., Pershouse, M.A., Jasser, S.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15 356-362 (1997).

Di Cristofano, A., and Pandolfi, P.P. The multiple roles of PTEN in tumor suppression. Cell 100 387-390 (2000).

Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

Dahia, P.L.M. PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7 115-129 (2000).

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Size	Price	Quantity	Subtotal
1 ea	$107.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Acid Phosphatase Assay Kit

PH Domain Leucine-rich Repeat Protein Phosphatase 1 Polyclonal Antibody

PTEN Polyclonal Antibody

PTEN Western Ready Control

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Downloads

	Download Product Insert 78 Kb PDF
	Download Material Safety Data Sheet (MSDS) 70 Kb PDF
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	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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