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2-cyano-Pyrimidine

Cayman Chemical Item Number 10007121

(CAS 14080-23-0)

2-cyano-Pyrimidine (CAS 14080-23-0)

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Description

Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis.1 2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and derivatives are being studied for the treatment of osteoporosis. 2-cyano-Pyrimidine has an IC50 value of 170 nM for inhibition of cathepsin K.2

1 Altmann, E., Aichholz, R., Betschart, C., et al. 2-cyano-pyrimidines: A new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem 50(4) 591-594 (2007).

2 Carroll, J., Smith, N., and Babson, A.L. A colorimetric serum glucose determination using hexokinase and glucose-6-phosphate dehydrogenase. Biochem Med 4 171-180 (1970).

Formal Name 2-​pyrimidinecarbonitrile
CAS Number 14080-23-0
Molecular Formula C5H3N3
Formula Weight 124.1
Formulation A crystalline solid
Purity >98%
λmax 213, 254 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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NCc1ncccn1

Background Reading

Altmann, E., Aichholz, R., Betschart, C., et al. 2-cyano-pyrimidines: A new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem 50(4) 591-594 (2007).

Size Price Quantity Subtotal
500 mg $7.00 $0.00
1 g $14.00 $0.00
5 g $63.00 $0.00
10 g $112.00 $0.00
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Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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