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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Leukotriene C4 methyl ester

Cayman Chemical Item Number 10007164

LTC4 methyl ester (CAS 73958-10-8)

Leukotriene C4 methyl ester (CAS 73958-10-8)

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Description

Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets.1 It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.2 LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.3,4 The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.4 LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported.

1 Maclouf, J.A., and Murphy, R.C. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4. J Biol Chem 263 174-181 (1988).

2 Piper, P.J. Formation and actions of leukotrienes. Physiol Rev 64 744-761 (1984).

3 Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

4 Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

Synonyms
  • LTC4 methyl ester
Formal Name 5S-​hydroxy-​6R-​(S-​glutathionyl)-​7E,​9E,​11Z,​14Z-​eicosatetraenoic acid,​ methyl ester
CAS Number 73958-10-8
Molecular Formula C31H49N3O9S
Formula Weight 639.8
Formulation A solution in ethanol
Purity >97%
λmax 280 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)​(C(=O)​NCC(=O)​O)​N1C(=O)​CCC1C(=O)​O)​[C@@H]​(O)​CCCC(=O)​OC

Background Reading

Maclouf, J.A., and Murphy, R.C. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4. J Biol Chem 263 174-181 (1988).

Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

Piper, P.J. Formation and actions of leukotrienes. Physiol Rev 64 744-761 (1984).

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Size Price Quantity Subtotal
25 µg $118.00 $0.00
50 µg $224.00 $0.00
100 µg $425.00 $0.00
500 µg $1,888.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

11-trans Leukotriene C4
Leukotriene C4
Leukotriene E4
Leukotriene E4 methyl ester
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