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Leukotriene D4 methyl ester

Cayman Chemical Item Number 10007165

Leukotriene D4 methyl ester

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Description

Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.1,2 LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.3,4 LTD4 is several hundred fold more potent than LTC4 at the cysteinyl-leukotriene 1 (CysLT1) receptor, but they exhibit approximately equal affinity at the CysLT2 receptor.5,6 LTD4 methyl ester is a more lipid soluble form of LTD4. The biological activity of LTD4 methyl ester has not been reported.

1 Örning, L., Hammarström, S., and Samuelsson, B. Leukotriene D: A slow reacting substance from rat basophilic leukemia cells. Proc Natl Acad Sci USA 77 2014-2017 (1980).

2 Hammarström, S., Örning, L., and Bernström, K. Metabolism of leukotrienes. Mol Cell Biochem 69 7-16 (1985).

3 Hedqvist, P., Dahlén, S., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol Scand 110 331-333 (1980).

4 Samuelsson, B., Dahlén, S., Lindgren JÅ, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237 1171-1176 (1987).

5 Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

6 Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 275 30531-30536 (2000).

Formal Name 5S-​hydroxy-​6R-​(S-​cysteinylglycinyl)-​7E,​9E,​11Z,​14Z-​eicosatetraenoic acid,​ methyl ester
Molecular Formula C26H42N2O6S
Formula Weight 510.7
Formulation A solution in ethanol
Purity >97%
λmax 280 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)​C(=O)​NCC(=O)​O)​[C@@H]​(O)​CCCC(=O)​OC

Background Reading

Hammarström, S., Örning, L., and Bernström, K. Metabolism of leukotrienes. Mol Cell Biochem 69 7-16 (1985).

Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 275 30531-30536 (2000).

Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

Örning, L., Hammarström, S., and Samuelsson, B. Leukotriene D: A slow reacting substance from rat basophilic leukemia cells. Proc Natl Acad Sci USA 77 2014-2017 (1980).

Samuelsson, B., Dahlén, S., Lindgren JÅ, et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237 1171-1176 (1987).

Hedqvist, P., Dahlén, S., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol Scand 110 331-333 (1980).

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Size Price Quantity Subtotal
25 µg $118.00 $0.00
50 µg $224.00 $0.00
100 µg $425.00 $0.00
500 µg $1,888.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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