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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Leukotriene E4 methyl ester

Cayman Chemical Item Number 10007166

Leukotriene E4 methyl ester

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Description

Leukotriene E4 (LTE4) is produced by the action of a dipeptidase on LTD4 leaving only the cysteinyl group still attached to the fatty acid backbone.1 It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).2 LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl LTs.1,3 Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.4,5,6 LTE4 methyl ester is a more lipid soluble form of LTE4. The biological activity of LTE4 methyl ester has not been reported.

1 Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. J Biol Chem 256 9579-9582 (1981).

2 Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

3 Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

4 Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. Clin Exp Allergy 25 467-479 (1995).

5 Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 146 104-108 (1992).

6 Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis 146 96-103 (1992).

Formal Name 5S-​hydroxy-​6R-​(S-​cysteinyl)-​7E,​9E,​11Z,​14Z-​eicosatetraenoic acid,​ methyl ester
Molecular Formula C24H39NO5S
Formula Weight 453.6
Formulation A solution in ethanol
Purity >97%
λmax 281 nm
ε 40
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)​C(=O)​O)​[C@@H]​(O)​CCCC(=O)​OC

Background Reading

Bernström, K., and Hammarström, S. Metabolism of leukotriene D by porcine kidney. J Biol Chem 256 9579-9582 (1981).

Kumlin, M., Stensvad, F., Larsson, L., et al. Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. Clin Exp Allergy 25 467-479 (1995).

Lefer, A.M. Leukotrienes as mediators of ischemia and shock. Biochem Pharmacol 35 123-127 (1986).

Samuelsson, B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 220 568-575 (1983).

Drazen, J.M., O'Brien, J., Sparrow, D., et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 146 104-108 (1992).

Kumlin, M., Dahlén, B., Björck, T., et al. Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am Rev Respir Dis 146 96-103 (1992).

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Size Price Quantity Subtotal
25 µg $76.00 $0.00
50 µg $144.00 $0.00
100 µg $274.00 $0.00
500 µg $1,216.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Leukotriene E4
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