See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Microcystin-LR

Cayman Chemical Item Number 10007188

Cyanoginosin-LR (CAS 101043-37-2)

Microcystin-LR (CAS 101043-37-2)

See more

Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.1 They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase-2A (PP-2A) (IC50=0.04 nM) and will completely inhibit this enzyme without affecting PP-1 when used at a concentration of 0.5 nM.2 The PP-1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

1 Rinehart, K.L., Harada, K., Namikoshi, M., et al. Nodularin, microcystin, and the configuration of Adda. J Am Chem Soc 110 8557-8558 (1988).

2 Honkanen, R.E., Zwiller, J., Moore, R.E., et al. Characterization of microcystin-LR, a potent inhibitor of Type 1 and Type 2A protein phosphatases. J Biol Chem 265(32) 19401-19404 (1990).

Synonyms
  • Cyanoginosin-LR
Formal Name Toxin T 17 (Microcystis aeruginosa)
CAS Number 101043-37-2
Molecular Formula C49H74N10O12
Formula Weight 995.2
Formulation A solution in ethanol
Purity >95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
COC(Cc1ccccc1)​C(C)​\C=C(/C)​\C=C\[C@H]​1NC(=O)​[C@H]​(CCCNC(=N)​N)​NC(=O)​[C@@H]​(C)​C(NC(=O)​[C@H]​(CC(C)​C)​NC(=C)​[C@@H]​(C)​NC(=C)​C(=C)​N(C)​C(=C)​CCC(NC(=O)​C1C)​C(=O)​O)​C(=O)​O

Background Reading

Rinehart, K.L., Harada, K., Namikoshi, M., et al. Nodularin, microcystin, and the configuration of Adda. J Am Chem Soc 110 8557-8558 (1988).

Honkanen, R.E., Zwiller, J., Moore, R.E., et al. Characterization of microcystin-LR, a potent inhibitor of Type 1 and Type 2A protein phosphatases. J Biol Chem 265(32) 19401-19404 (1990).
Size Price Quantity Subtotal
50 µg $23.00 $0.00
100 µg $44.00 $0.00
500 µg $184.00 $0.00
1 mg $322.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Nodularin

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?