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10007191 PH Domain Leucine-rich Repeat Protein Phosphatase Polyclonal Antibody
Suprachiasmatic Nucleus Circadian Oscillatory Protein; SCOP; PLEKHE1 Protein; PHLPP; KIAA0606 Protein
PH Domain Leucine-rich Repeat Protein Phosphatase Polyclonal Antibody Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Antigen:
synthetic peptide from human PH Domain Leucine-rich Repeat Protein Phosphatase (PHLPP) amino acids 1192-1205 (YQLDQLPDYYDTPL)
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Host:
rabbit
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Application(s):
WB, ICC, and IHC (paraffin-embedded sections); other applications not tested
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Protein kinase B/Akt is critical in regulating cell growth and death. Activation of a serine residue (Ser473) in a C-terminal hydrophobic motif of Akt is known to be linked to some of the most common human cancers. PHLPP dephosphorylates the hydrophobic motif of Akt and thus reduces Akt activity, resulting in a increase in the number of apoptotic cells.1 PHLPP levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation. Injection of a human glioblastoma cell line overexpressing PHLPP into mice reduced tumor size by nearly 70% compared with control animals. mRNA of PHLPP is ubiquitously expressed, with highest levels found in brain.1 Human PHLPP is 1,205 amino acid in length with an estimated molecular weight of 134 kDa. Cayman’s PHLPP polyclonal antibody detects the enzyme at around 150 kDa by western blot from tissues such as brain.
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1
Gao, T., Furnari, F., Newton, A.C. PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular Cell 18 13-24 (2005).
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Purchase 10007191 PH Domain Leucine-rich Repeat Protein Phosphatase Polyclonal Antibody
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
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for a quote or to purchase.
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Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-14.
Prices are subject to change without notice.
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