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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PH Domain Leucine-rich Repeat Protein Phosphatase Blocking Peptide

Cayman Chemical Item Number 10007192

Suprachiasmatic Nucleus Circadian Oscillatory Protein; SCOP; PLEKHE1 Protein; PHLPP; KIAA0606 Protein

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Description

Peptide sequence: PH Domain Leucine-rich Repeat Protein Phosphatase (PHLPP) amino acids 1192-1205 (YQLDQLPDYYDTPL) · To be used in conjunction with Cayman’s PHLPP polyclonal antibody (Catalog No. 10007191) to block protein-antibody complex formation during immunochemical analysis of PHLPP · Protein kinase B/Akt is critical in regulating cell growth and death. Phosphorylation of a serine residue (Ser473) in a C-terminal hydrophobic motif of Akt is known to be linked to some of the most common human cancers. PHLPP dephosphorylates the hydrophobic motif of Akt and thus reduces Akt activity, resulting in a increase in the number of apoptotic cells.1 PHLPP levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation. Injection of a human glioblastoma cell line overexpressing PHLPP into mice reduced tumor size by nearly 70% compared with control animals. mRNA of PHLPP is ubiquitously expressed, with highest levels found in brain.1

1 Gao, T., Furnari, F., and Newton, A.C. PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18 13-24 (2005).

Synonyms
  • Suprachiasmatic Nucleus Circadian Oscillatory Protein
  • SCOP
  • PLEKHE1 Protein
  • PHLPP
  • KIAA0606 Protein
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Gao, T., Furnari, F., and Newton, A.C. PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18 13-24 (2005).
Size Price Quantity Subtotal
1 ea $107.00 $0.00
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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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