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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

6-keto Prostaglandin E1 Lipid Maps MS Standard

Cayman Chemical Item Number 10007210

6-keto PGE1 (CAS 67786-53-2)

6-keto Prostaglandin E1 Lipid Maps MS Standard (CAS 67786-53-2)

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Description

6-keto Prostaglandin E1 (6-keto PGE1) is a stable non-enzymatic hydrolysis product of prostacyclin (PGI2). 6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.1 However, it is not produced in appreciable amounts following IV infusion of PGI2 in humans.2 6-keto PGE1 is equipotent with PGI2 as a vasodilator; in most other aspects its activity resembles PGE1.3

1 Wong, P.Y., Malik, K.U., Desiderio, D.M., et al. Hepatic metabolism of prostacyclin (PGI2) in the rabbit: Formation of a potent novel inhibitor of platelet aggregation. Biochem Biophys Res Commun 93 486-494 (1980).

2 Jackson, E.K., Goodman, R.P., Fitzgerald, G.A., et al. Assessment of the extent to which exogenous prostaglandin I2 is converted to 6-keto-prostaglandin E1 in human subjects. J Pharmacol Exp Ther 221 183-187 (1982).

3 Adaikan, P.G., Tai, M.Y., Lau, L.C., et al. A comparison of some pharmacological actions of prostaglandin D2, 6-oxo-PGE1 and PGI2. Prostaglandins 27 505-516 (1984).

Synonyms
  • 6-keto PGE1
Formal Name 6,​9-​dioxo-​11α,​15S-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 67786-53-2
Molecular Formula C20H32O6
Formula Weight 368.5
Formulation A crystalline solid
Purity >99%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(=O)​C1CC(=O)​CCCCC(=O)​O

Background Reading

Adaikan, P.G., Tai, M.Y., Lau, L.C., et al. A comparison of some pharmacological actions of prostaglandin D2, 6-oxo-PGE1 and PGI2. Prostaglandins 27 505-516 (1984).

Wong, P.Y., Malik, K.U., Desiderio, D.M., et al. Hepatic metabolism of prostacyclin (PGI2) in the rabbit: Formation of a potent novel inhibitor of platelet aggregation. Biochem Biophys Res Commun 93 486-494 (1980).

Jackson, E.K., Goodman, R.P., Fitzgerald, G.A., et al. Assessment of the extent to which exogenous prostaglandin I2 is converted to 6-keto-prostaglandin E1 in human subjects. J Pharmacol Exp Ther 221 183-187 (1982).
Size Price Quantity Subtotal
1 mg $71.00 $0.00
5 mg $320.00 $0.00
10 mg $568.00 $0.00
50 mg $2,485.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

6-keto Prostaglandin E1
Prostaglandin E1
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