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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

2,3-dinor-11β-Prostaglandin F2α Lipid Maps MS Standard

Cayman Chemical Item Number 10007225

2,3-dinor-11β-PGF2α (CAS 240405-20-3)

2,3-dinor-11β-Prostaglandin F2α Lipid Maps MS Standard (CAS 240405-20-3)

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Description

2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiolabeled dose, respectively.1 2,3-dinor-11β-PGF2α has also been recovered from the urine of mastocytosis patients, where it is excreted in large amounts.2 In human asthmatic patients, 2,3-dinor-11β-PGF2α represents about 40% (as determined by GC/MS) of the immunoreactive 11β-PGF2α when measured using Cayman’s 11β-PGF2α EIA Kit (Catalog No. 516521). The excretion rate for 2,3-dinor-11β-PGF2α is approximately 200-250 ng/24 hours in a normal adult.3

1 Liston, T.E., and Roberts, L.J. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J Biol Chem 260 13172-13180 (1985).

2 Roberts, L.J., and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30 383-400 (1985).

3 O'Sullivan, S., Mueller, M.J., Dahlén, S., et al. Analyses of prostaglandin D2 metabolites in urine: Comparison between enzyme immunoassay and negative ion chemical ionization gas chromatography-mass spectrometry. Prostaglandins Other Lipid Mediat 57 149-165 (1999).

Synonyms
  • 2,3-dinor-11β-PGF2α
Formal Name 9α,​11β,​15S-​trihydroxy-​2,​3-​dinor-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 240405-20-3
Molecular Formula C18H30O5
Formula Weight 326.4
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1[C@@H]​(O)​CC(O)​C1C/C=C\CC(=O)​O

Background Reading

Roberts, L.J., and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30 383-400 (1985).

O'Sullivan, S., Mueller, M.J., Dahlén, S., et al. Analyses of prostaglandin D2 metabolites in urine: Comparison between enzyme immunoassay and negative ion chemical ionization gas chromatography-mass spectrometry. Prostaglandins Other Lipid Mediat 57 149-165 (1999).

Liston, T.E., and Roberts, L.J. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J Biol Chem 260 13172-13180 (1985).
Size Price Quantity Subtotal
25 µg $94.00 $0.00
50 µg $179.00 $0.00
100 µg $338.00 $0.00
500 µg $1,504.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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