See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

11-dehydro Thromboxane B2 Lipid Maps MS Standard

Cayman Chemical Item Number 10007239

11-dehydro TXB2; 11-keto TXB2 (CAS 67910-12-7)

11-dehydro Thromboxane B2 Lipid Maps MS Standard (CAS 67910-12-7)

See more

Description

Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.1 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis.1,2,3,4 The mean plasma level in human males is 0.9-4.3 pg/ml and the half life is 45-60 minutes.2,3,4 Urinary concentrations of 11-dehydro TXB2 are approximately 30-70 ng/mmol creatinine.5,6

1 Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989).

2 Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985).

3 Takasaki, W., Nakagawa, A., Tanaka, Y., et al. Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. Thromb Res 63 331-341 (1991).

4 Catella, F., Healy, D., Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci USA 83 5861-5865 (1986).

5 Lellouche, F., Fradin, A., FitzGerald, G., et al. Enzyme immunoassay measurement of the urinary metabolites of thromboxane A2 and prostacyclin. Prostaglandins 40 297-310 (1990).

6 Perneby, C., Granström, E., Beck, O., et al. Optimization of an enzyme immunoassay for 11-dehydro-thromboxane B2 in urine: Comparison with GC-MS. Thromb Res 96 427-436 (1999).

Synonyms
  • 11-dehydro TXB2
  • 11-keto TXB2
Formal Name 9α,​15S-​dihydroxy-​11-​oxothromba-​5Z,​13E-​dien-​1-​oic acid
CAS Number 67910-12-7
Molecular Formula C20H32O6
Formula Weight 368.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCC(O)​/C=C/[C@H]​1OC(=O)​CC(O)​C1C/C=C\CCCC(=O)​O

Background Reading

Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985).

Perneby, C., Granström, E., Beck, O., et al. Optimization of an enzyme immunoassay for 11-dehydro-thromboxane B2 in urine: Comparison with GC-MS. Thromb Res 96 427-436 (1999).

Lellouche, F., Fradin, A., FitzGerald, G., et al. Enzyme immunoassay measurement of the urinary metabolites of thromboxane A2 and prostacyclin. Prostaglandins 40 297-310 (1990).

Catella, F., Healy, D., Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci USA 83 5861-5865 (1986).

Takasaki, W., Nakagawa, A., Tanaka, Y., et al. Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. Thromb Res 63 331-341 (1991).

Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989).

Show all 6 Hide all but first 3
Size Price Quantity Subtotal
100 µg $139.00 $0.00
250 µg $330.00 $0.00
500 µg $626.00 $0.00
1 mg $1,112.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

11-dehydro-2,3-dinor Thromboxane B2
11-dehydro Thromboxane B2
11-dehydro Thromboxane B2-d4
11-dehydro Thromboxane B2 Quant-PAK
2,3-dinor Thromboxane B2
Thromboxane B2
Thromboxane B2-d4
Show all 7 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?