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Leukotriene B4 Lipid Maps MS Standard

Cayman Chemical Item Number 10007240

LTB4 (CAS 71160-24-2)

Leukotriene B4 Lipid Maps MS Standard (CAS 71160-24-2)

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Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes.4 At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5

1 Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

2 Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

3 McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. J Biol Chem 260 12832-12837 (1985).

4 Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit Rev Immunol 10 1-12 (1990).

5 McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24 114-119 (1988).

Synonyms
  • LTB4
Formal Name 5S,​12R-​dihydroxy-​6Z,​8E,​10E,​14Z-​eicosatetraenoic acid
CAS Number 71160-24-2
Molecular Formula C20H32O4
Formula Weight 336.5
Formulation A solution in ethanol
Purity ≥97%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C[C@@H]​(O)​/C=C/C=C\C=C\[C@@H]​(O)​CCCC(=O)​O

Background Reading

Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit Rev Immunol 10 1-12 (1990).

Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24 114-119 (1988).

McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. J Biol Chem 260 12832-12837 (1985).

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Size Price Quantity Subtotal
25 µg $123.00 $0.00
50 µg $234.00 $0.00
100 µg $442.00 $0.00
500 µg $1,968.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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LY255283
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