Cayman Chemical | 12(R)-HETE Lipid Maps MS Standard

10007247 12(R)-HETE Lipid Maps MS Standard

(CAS 82337-46-0)

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• See more Mass Spectrometry; Lipoxygenase; Oxylipins; Cytochrome P450; Inflammation

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Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid.¹ In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation.^2,3 The activity of 12(R)-HETE in mammals is predominantly proinflammatory.² 12(R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.

1 Hawkins, D.J., Brash, A.R. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity. J Biol Chem 262 7629-7634 (1987).

2 Schwartzman, M.L., Balazy, M., Masferrer, J., et al. 12(R)-Hydroxyeicosatetraenoic acid: A cytochrome P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea. Proc Natl Acad Sci USA 84 8125-8129 (1987).

3 Capdevila, J., Yadagiri, P., Manna, S., et al. Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450. Biochem Biophys Res Commun 141 1007-1011 (1986).

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Pricing updated 2010-03-17.
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