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12-OxoETE Lipid Maps MS Standard

Cayman Chemical Item Number 10007249

12-KETE (CAS 108437-64-5)

12-OxoETE Lipid Maps MS Standard (CAS 108437-64-5)

See more	Mass Spectrometry (253) Oxylipins (226)

Description

12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid.^1,2 Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE.^1,3 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via an Leukotriene B₄ receptor or a common activation sequence.⁴

1 Falgueyret, J., Leblanc, Y., and Riendeau, D. Stereoselective carbonyl reductases from rat skin and leukocyte microsomes converting 12-ketoeicosatetraenoic acid to 12(S)-HETE. FEBS Lett 262 197-200 (1990).

2 Fruteau De Laclos, B., Maclouf, J., Poubelle, P., et al. Conversion of arachidonic acid into 12-oxo derivatives in human platelets. A pathway possibly involving the heme-catalysed transformation of 12-hydroperoxy-eicosatetraenoic acid. Prostaglandins 33 315-337 (1987).

3 Falgueyret, J., Leblanc, Y., Rokach, J., et al. NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes. Biochem Biophys Res Commun 156 1083-1089 (1988).

4 Naccache, P.H., Leblanc, Y., Rokach, J., et al. Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: Evidence for the involvement of the leukotriene B₄ receptor. Biochim Biophys Acta 1133 102-106 (1991).

Synonyms	12-KETE
Formal Name	12-oxo-5Z,8Z,10E,14Z-eicosatetraenoic acid
CAS Number	108437-64-5
Molecular Formula	C₂₀H₃₀O₃
Formula Weight	318.5
Formulation	A solution in ethanol
Purity	≥90%
Stability	6 months
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\CC(=O)/C=C\C=C\C/C=C\CCCC(=O)O

Background Reading

Naccache, P.H., Leblanc, Y., Rokach, J., et al. Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: Evidence for the involvement of the leukotriene B₄ receptor. Biochim Biophys Acta 1133 102-106 (1991).

Falgueyret, J., Leblanc, Y., Rokach, J., et al. NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes. Biochem Biophys Res Commun 156 1083-1089 (1988).

Fruteau De Laclos, B., Maclouf, J., Poubelle, P., et al. Conversion of arachidonic acid into 12-oxo derivatives in human platelets. A pathway possibly involving the heme-catalysed transformation of 12-hydroperoxy-eicosatetraenoic acid. Prostaglandins 33 315-337 (1987).

Falgueyret, J., Leblanc, Y., and Riendeau, D. Stereoselective carbonyl reductases from rat skin and leukocyte microsomes converting 12-ketoeicosatetraenoic acid to 12(S)-HETE. FEBS Lett 262 197-200 (1990).

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Size	Price	Quantity	Subtotal
25 µg	$116.00		$0.00
50 µg	$220.00		$0.00
100 µg	$418.00		$0.00
250 µg	$928.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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