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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

12(S)-HHTrE Lipid Maps MS Standard

Cayman Chemical Item Number 10007250

12-HHT (CAS 54397-84-1)

12(S)-HHTrE Lipid Maps MS Standard (CAS 54397-84-1)

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Description

12(S)-HHTrE is an unusual product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of the human platelet.1 It is biosynthesized by thromboxane (TX) synthesis from prostaglandin H2 (PGH2) concurrently with TXA2. The biological role of 12(S)-HHTrE is uncertain. It is avidly oxidized to 12-oxoHTrE by porcine 15-hydroxy PGDH.2

1 Diczfalusy, U., Falardeau, P., and Hammarström, S. Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase. FEBS Lett 84 271-274 (1977).

2 Liu, Y., Yoden, K., Shen, R., et al. 12-L-Hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochem Biophys Res Commun 129 268-274 (1985).

Synonyms
  • 12-HHT
Formal Name 12S-​hydroxy-​5Z,​8E,​10E-​heptadecatrienoic acid
CAS Number 54397-84-1
Molecular Formula C17H28O3
Formula Weight 280.4
Formulation A solution in ethanol
Purity ≥97%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​\C=C\C=C/C/C=C\CCCC(=O)​O

Background Reading

Diczfalusy, U., Falardeau, P., and Hammarström, S. Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase. FEBS Lett 84 271-274 (1977).

Liu, Y., Yoden, K., Shen, R., et al. 12-L-Hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochem Biophys Res Commun 129 268-274 (1985).
Size Price Quantity Subtotal
25 µg $109.00 $0.00
50 µg $207.00 $0.00
100 µg $392.00 $0.00
250 µg $872.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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