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5(S),6(R)-DiHETE Lipid Maps MS Standard

Cayman Chemical Item Number 10007252

(CAS 82948-88-7)

5(S),6(R)-DiHETE Lipid Maps MS Standard (CAS 82948-88-7)

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Description

5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE.1 It is a weak LTD4 receptor agonist in guinea pig lung membranes.2 It induces guinea pig ileum contraction with an ED50 value of 1.3 µM.2

1 Haeggström, J., Wetterholm, A., Hamberg, M., et al. Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: Kinetics of the reaction and stereochemistry of the product. Biochim Biophys Acta 958 469-476 (1988).

2 Muller, A., Rechencq, E., Kugel, C., et al. Comparative biological activities of the four synthetic (5,6)-diHETE isomers. Prostaglandins 38 635-644 (1989).

Formal Name 5S,​6R-​dihydroxy-​7E,​9E,​11Z,​14Z-​eicosatetraenoic acid
CAS Number 82948-88-7
Molecular Formula C20H32O4
Formula Weight 336.5
Formulation A solution in ethanol
Purity >99%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C/C=C\C=C/C(O)​[C@@H]​(O)​CCCC(=O)​O

Background Reading

Muller, A., Rechencq, E., Kugel, C., et al. Comparative biological activities of the four synthetic (5,6)-diHETE isomers. Prostaglandins 38 635-644 (1989).

Haeggström, J., Wetterholm, A., Hamberg, M., et al. Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: Kinetics of the reaction and stereochemistry of the product. Biochim Biophys Acta 958 469-476 (1988).

Size Price Quantity Subtotal
25 µg $94.00 $0.00
50 µg $179.00 $0.00
100 µg $338.00 $0.00
250 µg $752.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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5(S),6(S)-DiHETE

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