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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

5(S)-HpETE Lipid Maps MS Standard

Cayman Chemical Item Number 10007257

(CAS 71774-08-8)

5(S)-HpETE Lipid Maps MS Standard (CAS 71774-08-8)

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Description

5(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 5-LO on arachidonic acid. It is metabolized to leukotriene A4 (LTA4), a key intermediate in the formation of LTs.1 5(S)-HpETE (1 µM) mediates the induction of the proto-oncogene c-fos in TNF-stimulated TA1 cells.2

1 Shimizu, T., Rådmark, O., and Samuelsson, B. Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. Proc Natl Acad Sci USA 81 689-693 (1984).

2 Haliday, E.M., Ramesha, C.S., and Ringold, G. TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite. EMBO J 10 109-115 (1991).

Formal Name 5S-​hydroperoxy-​6E,​8Z,​11Z,​14Z-​eicosatetraenoic acid
CAS Number 71774-08-8
Molecular Formula C20H32O4
Formula Weight 336.5
Formulation A solution in ethanol
Purity ≥98%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C=C/C(OO)​CCCC(=O)​O

Background Reading

Haliday, E.M., Ramesha, C.S., and Ringold, G. TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite. EMBO J 10 109-115 (1991).

Shimizu, T., Rådmark, O., and Samuelsson, B. Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. Proc Natl Acad Sci USA 81 689-693 (1984).

Size Price Quantity Subtotal
25 µg $83.00 $0.00
50 µg $158.00 $0.00
100 µg $299.00 $0.00
250 µg $664.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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5(S)-HpETE

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