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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

6-keto Prostaglandin F1α-d4 Lipid Maps MS Standard

Cayman Chemical Item Number 10007274

6-keto PGF1α-d4

6-keto Prostaglandin F1α-d4 Lipid Maps MS Standard

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Description

6-keto Prostaglandin F1α-d4 (6-keto PGF1α-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry.6-keto prostaglandin F1α (6-keto PGF1α) is the inactive, non-enzymatic hydrolysis product of PGI2.1,2 6-keto PGF1α serves as a useful marker of PGI2 biosynthesis in vivo.3 When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α.3

1 Pace-Asciak, C.R. Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1α in the rat stomach. J Am Chem Soc 98 2348-2349 (1976).

2 Johnson, R.A., Morton, D.R., Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins 12 915-928 (1976).

3 Brash, A.R., Jackson, E.K., Saggese, C.A., et al. Metabolic disposition of prostacyclin in humans. J Pharmacol Exp Ther 226 78-87 (1983).

Synonyms
  • 6-keto PGF1α-d4
Formal Name 6-​oxo-​9α,​11α,​15S-​trihydroxy-​prost-​13E-​en-​1-​oic-​3,​3,​4,​4-​d4 acid
Molecular Formula C20H30D4O6
Formula Weight 374.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​CC[C@H]​1C(O)​CC(O)​C1CC(=O)​CCCCC(=O)​O

Background Reading

Johnson, R.A., Morton, D.R., Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins 12 915-928 (1976).

Pace-Asciak, C.R. Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1α in the rat stomach. J Am Chem Soc 98 2348-2349 (1976).

Brash, A.R., Jackson, E.K., Saggese, C.A., et al. Metabolic disposition of prostacyclin in humans. J Pharmacol Exp Ther 226 78-87 (1983).
Size Price Quantity Subtotal
25 µg $54.00 $0.00
50 µg $103.00 $0.00
100 µg $194.00 $0.00
1 mg $1,512.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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