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Arachidonic Acid-d8 Lipid Maps MS Standard

Cayman Chemical Item Number 10007277

(CAS 69254-37-1)

Arachidonic Acid-d8 Lipid Maps MS Standard (CAS 69254-37-1)

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Description

Arachidonic acid-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of arachidonic acid by GC- or LC-mass spectrometry. Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways.1 Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-update of free arachidonate are all important aspects of cell signaling and inflammation.2

1 Burgoyne, R.D., and Morgan, A. The control of free arachidonic acid levels. Trends Biochem Sci 15 365-366 (1990).

2 Nixon, A.B., Greene, D.G., and Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. Biochim Biophys Acta 1300 187-196 (1996).

Formal Name 5Z,​8Z,​11Z,​14Z-​eicosatetraenoic-​5,​6,​8,​9,​11,​12,​14,​15-​d8 acid
CAS Number 69254-37-1
Molecular Formula C20H24D8O2
Formula Weight 312.5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d8)
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​O

Background Reading

Nixon, A.B., Greene, D.G., and Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. Biochim Biophys Acta 1300 187-196 (1996).

Burgoyne, R.D., and Morgan, A. The control of free arachidonic acid levels. Trends Biochem Sci 15 365-366 (1990).

Size Price Quantity Subtotal
1 mg $96.00 $0.00
5 mg $432.00 $0.00
10 mg $768.00 $0.00
50 mg $3,360.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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FAQs

It appears that there is a heterogenous mixture of deuterated species in your deuterated standards; is this normal?

Yes, this is typical of our deuterated products. Our deuterated products contain less than 1 % d0. However, the labeled compounds are not 100% of the deuterated form listed on our product insert. For example, upon analysis of 2-arachidonoyl glycerol-d8 it is expected to see masses associated with the d7, d6, d5 etc.

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