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Resolvin D2 Exclusive

Cayman Chemical Item Number 10007279

7(S),16(R),17(S)-Resolvin D2 (CAS 810668-37-2)

Resolvin D2 (CAS 810668-37-2)

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Description

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.3 It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.3 Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.3

1 Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).

2 Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).

3 Spite, M., Norling, L.V., Summers, L., et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461(7268) 1287-1291 (2009).

Synonyms
  • 7(S),16(R),17(S)-Resolvin D2
Formal Name 7S,​16R,​17S-​trihydroxy-​4Z,​8E,​10Z,​12E,​14E,​19Z-​docosahexaenoic acid
CAS Number 810668-37-2
Molecular Formula C22H32O5
Formula Weight 376.5
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C[C@H]​(O)​[C@H]​(O)​/C=C/C=C/C=C\C=C\[C@@H]​(O)​C/C=C\CCC(O)​=O\C=C\C=C/[C@@H]​(O)​C/C=C\CCC(=O)​O

Background Reading

Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).

Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).

Spite, M., Norling, L.V., Summers, L., et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461(7268) 1287-1291 (2009).
Size Price Quantity Subtotal
10 µg $123.00 $0.00
25 µg $292.00 $0.00
50 µg $554.00 $0.00
100 µg $984.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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