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Arachidonoyl amideCayman Chemical Item Number 10007295 Arachidonamide; Arachidonic Acid amide (CAS 85146-53-8) 
Arachidonoyl amide (CAS 85146-53-8)
Description
Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase (FAAH). Arachidonoyl amide is an analog of AEA that lacks the hydroxyethyl moiety. It is hydrolyzed by FAAH more effectively than AEA but exhibits significantly weaker binding to the human CB1 receptor with a Ki of 9.6 µM.1,2 Arachidonoyl amide and AEA exhibit similar binding and translocation into cells via the AEA transporter. It inhibits [3H]-
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Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor- 2 Lang, W., Qin, C., Lin, S., et al. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. J Med Chem 42 896-902 (1999). 3 Piomelli, D., Beltramo, M., Glasnapp, S., et al. Structural determinants for recognition and translocation by the anandamide transporter. Proc Natl Acad Sci USA 96 5802-5807 (1999).
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Boger, D.L., Sato, H., Lerner, A.E., et al. Arachidonic acid amide inhibitors of gap junction cell-
Background ReadingLang, W., Qin, C., Lin, S., et al. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. J Med Chem 42 896-902 (1999). Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor- Piomelli, D., Beltramo, M., Glasnapp, S., et al. Structural determinants for recognition and translocation by the anandamide transporter. Proc Natl Acad Sci USA 96 5802-5807 (1999). Boger, D.L., Sato, H., Lerner, A.E., et al. Arachidonic acid amide inhibitors of gap junction cell- Arachidonoyl amide is available in the following screening library: |
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