See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

9-Thiastearic Acid

Cayman Chemical Item Number 10007417

(CAS 106689-24-1)

9-Thiastearic Acid (CAS 106689-24-1)

See more

Description

Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools.1,2 9-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 µM.3 This activity is associated with a hypolipidemic effect, making this 9-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.

1 Wu, P., Grav, H.J., Horn, R., et al. Effects of chain length and sulphur position of thia fatty acids on their incorporation into phospholipids in 7800 C1 hepatoma cells and isolated rat hepatocytes, and their effects on fatty acid composition of phospholipids. Biochem Pharmacol 51 751-758 (1996).

2 Pascal, R.A., and Ziering, D.L. Synthesis of heteroatom-substituted analogues of stearic acid. J Lipid Res 27 221-224 (1986).

3 Høvik, K.E., Spydevold ØS, and Bremer, J. Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase. Biochim Biophys Acta 1349 251-256 (1997).

Formal Name 8-​(nonylthio)-​octanoic acid
CAS Number 106689-24-1
Molecular Formula C17H34O2S
Formula Weight 472.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCCCCCSCCCCCCCC(O)​=O

Background Reading

Wu, P., Grav, H.J., Horn, R., et al. Effects of chain length and sulphur position of thia fatty acids on their incorporation into phospholipids in 7800 C1 hepatoma cells and isolated rat hepatocytes, and their effects on fatty acid composition of phospholipids. Biochem Pharmacol 51 751-758 (1996).

Høvik, K.E., Spydevold ØS, and Bremer, J. Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase. Biochim Biophys Acta 1349 251-256 (1997).

Pascal, R.A., and Ziering, D.L. Synthesis of heteroatom-substituted analogues of stearic acid. J Lipid Res 27 221-224 (1986).

9-Thiastearic Acid is available in the following screening libraries:

Size Price Quantity Subtotal
5 mg $33.00 $0.00
10 mg $63.00 $0.00
50 mg $264.00 $0.00
100 mg $462.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

3-Thiatetradecanoic Acid
Stearic Acid ethyl ester
Stearoyl Ethanolamide

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?