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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

10-methyl-9-(phenoxycarbonyl) Acridinium fluorosulfonate

Cayman Chemical Item Number 10007464

PMAC (CAS 149300-54-9)

10-methyl-9-(phenoxycarbonyl) Acridinium fluorosulfonate (CAS 149300-54-9)

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Description

Acridinium esters can replace radioactive isotopes in numerous applications (e.g., immunoassays, antibody labeling, etc.).1,2 Their sensitivity is comparable to radiolabeled reagents without the disposal issues associated with radioactive waste. 10-methyl-9-(phenoxycarbonyl) Acridinium fluorosulfonate (PMAC) is a sensitive tool for detection of reactive oxygen species (ROS).3 When immobilized onto polymer microspheres, it can be phagocytized by cells and used as an internal ROS detector. The chemiluminescence of PMAC can be initiated using hypoxanthine/xanthine oxidase or hydrogen peroxide at physiological pH.

1 Weeks, I., Beheshti, I., McCapra, F., et al. Acridinium esters as high-specific-activity labels in immunoassay. Clin Chem 29 1474-1479 (1983).

2 Weeks, I., Sturgess, M., Brown, R.C., et al. Immunoassays using acridinium esters. Methods Enzymol 133 366-387 (1986).

3 Hosaka, S., Itagaki, T., and Kuramitsu, Y. Selectivity and sensitivity in the measurement of reactive oxygen species (ROS) using chemiluminescent microspheres prepared by the binding of acridinium ester of ABEI to polymer microspheres. Luminescence 14 349-354 (1999).

Synonyms
  • PMAC
Formal Name 10-​methyl-​9-​(phenoxycarbonyl)acridinium,​ fluorosulfate
CAS Number 149300-54-9
Molecular Formula C21H16FNO5S
Formula Weight 413.4
Formulation A crystalline solid
Purity >98%
λmax 203, 261, 286, 367 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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C[N+]​1=C(C=CC=C2)​C2=C(C(OC3=CC=CC=C3)​=O)​C4=C1C=CC=C4.O=S(F)​([O-]​)​=O

Background Reading

Weeks, I., Beheshti, I., McCapra, F., et al. Acridinium esters as high-specific-activity labels in immunoassay. Clin Chem 29 1474-1479 (1983).

Hosaka, S., Itagaki, T., and Kuramitsu, Y. Selectivity and sensitivity in the measurement of reactive oxygen species (ROS) using chemiluminescent microspheres prepared by the binding of acridinium ester of ABEI to polymer microspheres. Luminescence 14 349-354 (1999).

Weeks, I., Sturgess, M., Brown, R.C., et al. Immunoassays using acridinium esters. Methods Enzymol 133 366-387 (1986).
Size Price Quantity Subtotal
1 mg $54.00 $0.00
5 mg $243.00 $0.00
10 mg $432.00 $0.00
50 mg $1,890.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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