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Prorenin (human recombinant)

Cayman Chemical Item Number 10007599

See more	Enzyme Activity (146) Enzymes (119) Proteins (180) Endocrinology (335) Hypertension (90) Renal Disease (32)

Description

Source: recombinant enzyme expressed in HEK cells · M_r: 45 kDa · Prorenin is the inactive precursor of renin, which is a key enzyme in the regulation of blood pressure and electrolyte balance. In renal juxtaglomerular cells, sequential cleavage of the N-terminal 20 and 46 amino acids of preprorenin produces prorenin and active renin, respectively.¹ Renin catalyzes the conversion of angiotensinogen to angiotensin I.² Prorenin exhibits 5-10% of the proteolytic activity of renin, however, the blood circulating levels are 10 times higher.^3,4

1 Holzman, T.F., Chung, C.C., Edalji, R., et al. Recombinant human prorenin from CHO cells: Expression and purification. J Protein Chem 9(6) 663-672 (1990).

2 Imai, T., Miyazaki, H., Hirose, S., et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci USA 80 7405-7409 (1983).

3 Sealey, J.E., Atlas, S.A., and Laragh, J.H. Prorenin and other large molecular weight forms of renin. Endocr Rev 1(4) 365-391 (1980).

4 Heinrikson, R.L., Hui, J., Zürcher-Neely, H., et al. A structural model to explain the partial catalytic activity of human prorenin. Am J Hypertens 2 367-380 (1989).

Formulation	A solution in 50 mM Tris, pH 8.0
Purity	≥99% by SDS-PAGE
Stability	6 months
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere

Background Reading

Holzman, T.F., Chung, C.C., Edalji, R., et al. Recombinant human prorenin from CHO cells: Expression and purification. J Protein Chem 9(6) 663-672 (1990).

Heinrikson, R.L., Hui, J., Zürcher-Neely, H., et al. A structural model to explain the partial catalytic activity of human prorenin. Am J Hypertens 2 367-380 (1989).

Imai, T., Miyazaki, H., Hirose, S., et al. Cloning and sequence analysis of cDNA for human renin precursor. Proc Natl Acad Sci USA 80 7405-7409 (1983).

Sealey, J.E., Atlas, S.A., and Laragh, J.H. Prorenin and other large molecular weight forms of renin. Endocr Rev 1(4) 365-391 (1980).

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Size	Price	Quantity	Subtotal
25 µg	$214.00		$0.00
50 µg	$407.00		$0.00
100 µg	$770.00		$0.00
500 µg	$3,424.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Renin (human recombinant)

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Downloads

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	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
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	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

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