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10007630 Caspase-8 (human recombinant)
MCH5; MACH; FLICE
Caspase-8 (human recombinant) Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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Source:
recombinant enzyme expressed in E. coli and purified out of inclusion bodies
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Mr:
11 and 19 kDa processed fragments
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Caspase-8 is a member of the interleukin-1 converting enzyme (ICE) family of cysteine proteases. It exists in the cell as an inactive 55 kDa proenzyme. During apoptosis, procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed form of caspase-8 consists of large and small subunits which associate to form the active enzyme. Caspase-8 activates downstream caspases (caspase 3, 6, and 7) that cleave key cellular substrates and lead to apoptotic cell death.1,2
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1
Budihardjo, I., Oliver, H., Lutter, M., et al. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15 269-290 (1999).
2
Goyal, L. Cell death inhibition:Keeping caspases in check. Cell 104 805-808 (2001).
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Purchase 10007630 Caspase-8 (human recombinant)
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
Please contact our
Sales Department
for a quote or to purchase.
Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services.
To ask for assistance with one of our products please contact our Technical Help staff.
Warning This product is not for human or veterinary use.
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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