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10007662 L-Biopterin
NSC 339699; L-erythro-Biopterin
(CAS 22150-76-1)
L-Biopterin Workbook Links
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs).1 L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.2
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1
Schallreuter, K.U., Büttner, G., Pittelkow, M.R., et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun 204(1) 43-48 (1994).
2
Moore, J., Wood, J.M., Schallreuter, K.U. Evidence for specific complex formation between α-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infared fourier transform raman spectroscopy. Biochemistry 38 15317-15324 (1999).
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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