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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

L-Biopterin

Cayman Chemical Item Number 10007662

NSC 339699; L-erythro-Biopterin (CAS 22150-76-1)

L-Biopterin (CAS 22150-76-1)

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Description

L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs).1 L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.2

1 Schallreuter, K.U., Büttner, G., Pittelkow, M.R., et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun 204(1) 43-48 (1994).

2 Moore, J., Wood, J.M., and Schallreuter, K.U. Evidence for specific complex formation between α-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infared fourier transform raman spectroscopy. Biochemistry 38 15317-15324 (1999).

Synonyms
  • NSC 339699
  • L-erythro-Biopterin
Formal Name 2-​amino-​6-​[(1R,​2S)-​1,​2-​dihydroxypropyl]-​4(1H)-​pteridinone
CAS Number 22150-76-1
Molecular Formula C9H11N5O3
Formula Weight 237.2
Formulation A crystalline solid
Purity >98%
λmax 276, 348 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Nc1nc(=O)​c2nc(c[nH]​c2n1)​[C@@H]​(O)​C(C)​O

Background Reading

Schallreuter, K.U., Büttner, G., Pittelkow, M.R., et al. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun 204(1) 43-48 (1994).

Moore, J., Wood, J.M., and Schallreuter, K.U. Evidence for specific complex formation between α-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infared fourier transform raman spectroscopy. Biochemistry 38 15317-15324 (1999).
Size Price Quantity Subtotal
5 mg $31.00 $0.00
10 mg $59.00 $0.00
25 mg $140.00 $0.00
50 mg $248.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

7,8-dihydro-L-Biopterin
tetrahydro-L-Biopterin (hydrochloride)

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