|
10007672 LDL Receptor Blocking Peptide
Low-density Lipoprotein Receptor Blocking peptide; LDLR Blocking Peptide
LDL Receptor Blocking Peptide Workbook Links
Cayman offers a variety of analysis tools to assist you.
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
|
Cholesterol is an essential element of cell membranes and is carried around the body packaged in lipoproteins, mostly low-density lipoprotein (LDL). The LDL receptors (LDLR) are complex glycoproteins located on cell membranes to scavenge LDL from the blood and regulate plasma LDL cholesterol. LDLRs contain five primary domains: the ligand binding domain, the homology with the EGF precursor domain, the O-link sugars domain, the membrane-spanning region, and a cytoplasmic tail.1 In humans, more than 60% of the LDLRs are found in the liver.2 LDLRs expression is under hormonal control both in vivo and in vitro. Mutations in the LDLR gene cause disorders such as familial hypercholesterolemia and atherosclerosis.1
|
|
1
Goldstein, J.L., Brown, M.S., Anderson, R.G.W., et al. Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system. Annu Rev Cell Biol 1 1-39 (1985).
2
Rudling, M.J., Reihnér, E., Einarsson, K., et al. Low density lipoprotein receptor-binding activity in human tissues: Quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo. Proc Natl Acad Sci USA 87 3469-3473 (1990).
|
Purchase 10007672 LDL Receptor Blocking Peptide
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
Please contact our
Sales Department
for a quote or to purchase.
Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services.
To ask for assistance with one of our products please contact our Technical Help staff.
Warning This product is not for human or veterinary use.
|
Pricing updated 2010-03-11.
Prices are subject to change without notice.
|
|
|
|
|
