LDL Receptor Blocking Peptide

Cayman Chemical Item Number 10007672

Low-density Lipoprotein Receptor Blocking peptide; LDLR Blocking Peptide

Description

Cholesterol is an essential element of cell membranes and is carried around the body packaged in lipoproteins, mostly low-density lipoprotein (LDL). The LDL receptors (LDLR) are complex glycoproteins located on cell membranes to scavenge LDL from the blood and regulate plasma LDL cholesterol. LDLRs contain five primary domains: the ligand binding domain, the homology with the EGF precursor domain, the O-link sugars domain, the membrane-spanning region, and a cytoplasmic tail.¹ In humans, more than 60% of the LDLRs are found in the liver.² LDLRs expression is under hormonal control both in vivo and in vitro. Mutations in the LDLR gene cause disorders such as familial hypercholesterolemia and atherosclerosis.¹

1 Goldstein, J.L., Brown, M.S., Anderson, R.G.W., et al. Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system. Annu Rev Cell Biol 1 1-39 (1985).

2 Rudling, M.J., Reihnér, E., Einarsson, K., et al. Low density lipoprotein receptor-binding activity in human tissues: Quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo. Proc Natl Acad Sci USA 87 3469-3473 (1990).

Synonyms

Low-density Lipoprotein Receptor Blocking peptide
LDLR Blocking Peptide

Formulation

200 µg of peptide in 200 µl of TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

Goldstein, J.L., Brown, M.S., Anderson, R.G.W., et al. Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system. Annu Rev Cell Biol 1 1-39 (1985).

Rudling, M.J., Reihnér, E., Einarsson, K., et al. Low density lipoprotein receptor-binding activity in human tissues: Quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo. Proc Natl Acad Sci USA 87 3469-3473 (1990).