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N-(3-hydroxyphenyl)-Arachidonoyl amide Exclusive

Cayman Chemical Item Number 10007704

3-HPAA (CAS 183718-75-4)

N-(3-hydroxyphenyl)-Arachidonoyl amide (CAS 183718-75-4)

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Description

N-(3-hydroxyphenyl)-Arachidonoyl amide (3-HPA) is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), which is a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide (AEA).¹ 3-HPA is metabolized by both cyclooxygenase-1 (COX-1) and COX-2 and was found to selectively and irreversibly inhibit COX-2 with an IC₅₀ value of 2 µM.²

1 Beltramo, M., Stella, N., Calignano, A., et al. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094-1097 (1997).

2 Turman, M.V., Kinsgley, P.J., and Marnet, L.J. 9^th International conference on eicosanoids and other bioactive lipids in cancer, inflammation, and related diseases. (2005).

Synonyms	3-HPAA
Formal Name	N-(3-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
CAS Number	183718-75-4
Molecular Formula	C₂₆H₃₇NO₂
Formula Weight	395.6
Formulation	A solution in ethanol
Purity	>98%
λ_max	246, 282 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Nc1cccc(O)c1

Background Reading

Beltramo, M., Stella, N., Calignano, A., et al. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094-1097 (1997).

Turman, M.V., Kinsgley, P.J., and Marnet, L.J. 9^th International conference on eicosanoids and other bioactive lipids in cancer, inflammation, and related diseases. (2005).

N-(3-hydroxyphenyl)-Arachidonoyl amide is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$31.00		$0.00
10 mg	$59.00		$0.00
50 mg	$248.00		$0.00
100 mg	$434.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

AM404

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