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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt)

Cayman Chemical Item Number 10007762

Phosphatidylinositol-4,5-bisphosphate C-6 (sodium salt); DHPI-4,5-P2 (sodium salt)

PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt)

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Description

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(4,5)-P2 (1,2-dihexanoyl) is a synthetic analog of natural PtdIns featuring C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of PtdIns-4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

1 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Synonyms
  • Phosphatidylinositol-4,5-bisphosphate C-6 (sodium salt)
  • DHPI-4,5-P2 (sodium salt)
Formal Name 1-​(1,​2-​dihexanoylphosphatidyl)inositol-​4,​5-​bisphosphate,​ trisodium salt
Molecular Formula C21H38O19P3 · 3Na
Formula Weight 756.4
Formulation A lyophilized powder
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCC(=O)​OC(COC(=O)​CCCCC)​COP(=O)​(O)​OC1C(O)​[C@@H]​(C)​C(C)​[C@@H]​(C)​[C@H]​1O

Background Reading

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Size Price Quantity Subtotal
100 µg $48.00 $0.00
500 µg $216.00 $0.00
1 mg $384.00 $0.00
5 mg $1,680.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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