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PtdIns-(3,4,5)-P₃ (1,2-dioctanoyl) (sodium salt)

Cayman Chemical Item Number 10007764

Phosphatidylinositol-3,4,5-trisphosphate (sodium salt); DOPI-3,4,5-P₃ (sodium salt)

PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)

See more	Inositol Phosphates (78) Lipids (167) Phospholipids (58) Cell Biology (281) Signal Transduction (314)

Description

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.^1,2 PtdIns-(3,4,5)-P₃ (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The short fatty acid chains of this analog give it different physical properties including high solubility in aqueous media compared to naturally occurring PtdIns-(3,4,5)-P₃. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P₂; PIP₂), and triphosphates (PtdIns-P₃; PIP₃). Phosphorylation of PtdIns-(4,5)-P₂ by phosphoinositide (PI)-3-kinase initiates an intricate signalling cascade at the fore front of scientific research.³

1 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3 Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

Synonyms	Phosphatidylinositol-3,4,5-trisphosphate (sodium salt) DOPI-3,4,5-P3 (sodium salt)
Formal Name	1-(1,2-dioctanoylphosphatidyl)inositol-3,4,5-trisphosphate, tetrasodium salt
Molecular Formula	C₂₅H₄₆O₂₂P₄ · 4Na
Formula Weight	914.5
Formulation	A lyophilized powder
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCCCC(=O)OCC(COP(=O)(O)OC1[C@H](O)[C@H](C)C(C)[C@H](C)C1O)OC(=O)CCCCCCC

Background Reading

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Vivanco, I., and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2 489-501 (2002).

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Size	Price	Quantity	Subtotal
100 µg	$45.00		$0.00
500 µg	$203.00		$0.00
1 mg	$360.00		$0.00
5 mg	$1,575.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)

PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)

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PtdIns-(3,4,5)-P₃ (1,2-dioctanoyl) (sodium salt)