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19(S)-HETE Exclusive

Cayman Chemical Item Number 10007766

(CAS 115461-40-0)

19(S)-HETE (CAS 115461-40-0)

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Description

19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively.1 Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels.2 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.3,4

1 Laethem, R.M., Balazy, M., Falck, J.R., et al. Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. J Biol Chem 268(17) 12912-12918 (1993).

2 Carroll, M.A., Balazy, M., Margiotta, P., et al. Cytochrome P-450-dependent HETEs: Profile of biological activity and stimulation by vasoactive peptides. Am J Physiol 271 R863-R869 (1996).

3 Escalante, B., Falck, J.R., Yadagiri, P., et al. 19(S)-Hydroxyeicosatetraenoic acid is a potent simulator of renal Na+-K+-ATPase. Biochem Biophys Res Commun 152 1269-1274 (1988).

4 Quigley, R., Baum, M., Reddy, K.M., et al. Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport. Am J Physiol Renal Physiol 278 F949-F953 (2000).

Formal Name 19S-​hydroxy-​5Z,​8Z,​11Z,​14Z-​eicosatetraenoic acid
CAS Number 115461-40-0
Molecular Formula C20H32O3
Formula Weight 320.5
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC(O)​CCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​O

Background Reading

Escalante, B., Falck, J.R., Yadagiri, P., et al. 19(S)-Hydroxyeicosatetraenoic acid is a potent simulator of renal Na+-K+-ATPase. Biochem Biophys Res Commun 152 1269-1274 (1988).

Laethem, R.M., Balazy, M., Falck, J.R., et al. Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1. J Biol Chem 268(17) 12912-12918 (1993).

Quigley, R., Baum, M., Reddy, K.M., et al. Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport. Am J Physiol Renal Physiol 278 F949-F953 (2000).

Carroll, M.A., Balazy, M., Margiotta, P., et al. Cytochrome P-450-dependent HETEs: Profile of biological activity and stimulation by vasoactive peptides. Am J Physiol 271 R863-R869 (1996).

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Size Price Quantity Subtotal
25 µg $120.00 $0.00
50 µg $228.00 $0.00
100 µg $432.00 $0.00
500 µg $1,920.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

19(R)-HETE
20-HETE
20-HETE-d6

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