D-myo-Inositol-1-phosphate (sodium salt)

Cayman Chemical Item Number 10007777

Ins(1)P₁ (sodium salt); 1-IP₁ (sodium salt)

Description

D-myo-Inositol-1-phosphate (Ins(1)P₁) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.^1,2 The most studied InsP, Ins(1,4,5)P₃, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.^3,4 Binding of Ins(1,4,5)P₃ to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.^4,5 Ins(1)P₁ can be formed by PLC hydrolysis of phosphatidylinositol or by dephosphorylation of polyphosphate inositols such as Ins(1,3)P₂ by inositol polyphosphate 3-phosphatase.¹

1 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

2 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

3 Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

4 Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

5 Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Synonyms

Ins(1)P1 (sodium salt)
1-IP1 (sodium salt)

Formal Name

D-myo-inositol-1-hydrogen phosphate, monosodium salt

Molecular Formula

C₆H₁₂O₉P · Na

Formula Weight

282.1

Formulation

A lyophilized powder

Purity

≥98%

Stability

1 year

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

Copy SMILES to clipboard

O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OP([O-])(O)=O.[Na+]

Background Reading

Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

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D-myo-Inositol-1-phosphate (sodium salt) is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

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Subtotal

500 µg 
$28.00

$0.00

1 mg 
$53.00

$0.00

5 mg 
$224.00

$0.00

10 mg 
$392.00

$0.00

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D-myo-Inositol-1-phosphate (sodium salt)