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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

Cayman Chemical Item Number 10007783

1,4,5,6-IP4 (sodium salt); Ins(1,4,5,6)P4 (sodium salt)

D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

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Description

D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.1 Ins(1,4,5,6)P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway.1 Ins(1,4,5,6)P3 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)P3 at initiating Ca2+ release when injected into Xenopus oocytes.2

1 Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proc Natl Acad Sci USA 94 14456-14460 (1997).

2 DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. Am J Physiol Cell Physiol 35 C429-C436 (1994).

Synonyms
  • 1,4,5,6-IP4 (sodium salt)
  • Ins(1,4,5,6)P4 (sodium salt)
Formal Name D-​myo-​inositol-​1,​4,​5,​6-​tetra(hydrogen phosphate),​ tetrasodium salt
Molecular Formula C6H12O18P4 · 4Na
Formula Weight 588.0
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@H]​(O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@H]​(OP([O-]​)​(O)​=O)​[C@@H]​(OP([O-]​)​(O)​=O)​[C@@H]​1OP([O-]​)​(O)​=O.[Na+]​.[Na+]​.[Na+]​.[Na+]​

Background Reading

Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proc Natl Acad Sci USA 94 14456-14460 (1997).

DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. Am J Physiol Cell Physiol 35 C429-C436 (1994).
Size Price Quantity Subtotal
100 µg $110.00 $0.00
500 µg $495.00 $0.00
1 mg $880.00 $0.00
5 mg $3,850.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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